Brain protection against cerebral ischemia

[Brain protection against cerebral ischemia].

Previous clinical trials failed to show the benefit of several potentially protective drugs in acute ischemic stroke. However, there would be three main approaches for brain protection against stroke. The first is to develop a novel thrombolytic agent which is more efficient and safer than alteplase. Tenecteplase and desmoteplase are in progress as a new thrombolytic drug. The second strategy i...

Electroacupuncture and Brain Protection against Cerebral Ischemia: Specific Effects of Acupoints

Electroacupuncture (EA) has been shown to increase cerebral blood flow (CBF) and reduce ischemic infarction in the rat model of cerebral ischemia (middle cerebral artery occlusion, MCAO). Since multiple acupoints are recommended to treat cerebral ischemia, we performed this study to investigate if there is any variation in EA protection against cerebral ischemia with the stimulation of certain ...

Barbiturate protection in acute focal cerebral ischemia.

! Barbiturate Protection in Acute Focal Cerebral Ischemia • We have found that anesthetic technique modifies the neurological and pathological se-quelae of unilateral middle cerebral artery and internal carotid artery occlusion in dogs. Occlu-sion was performed in seven groups of six dogs during each of the following anesthetic regimens: light (0.8%) halothane, "awake," deep (1.9%) halothane, d...

Protection Against Ischemia and Reperfusion Injury

Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia.

BACKGROUND AND PURPOSE Carbon monoxide (CO) is a gaseous second messenger produced when heme oxygenase enzymes catabolize heme. We have demonstrated that CO can be therapeutic in ischemia-reperfusion brain injury; however, it is unclear whether CO can also offer protection in permanent ischemic stroke or what mechanism(s) underlies the effect. Heme oxygenase-1 neuroprotection was shown to be re...